Posted by The high occurrence of melanoma and its associated poor prognosis highlight the need for exploring new and innovative treatment strategies. In this context, the present study focuses on developing and characterizing an aqueous suspension of magnetite (Fe3O4) coated with β-cyclodextrin (Fe3O4@β-CD) as a potential nanosystem for melanoma therapy. This nanosystem demonstrated favorable physicochemical properties for biological applications, including successful complexation of Fe3O4 nanoparticles with β-cyclodextrin and an average size of 18.1 ± 2.1 nm. In vitro assessments showed that the Fe3O4@β-CD nanosystem is highly biocompatible with human keratinocytes (HaCaT) and exhibits selective antiproliferative effects on amelanotic human melanoma (A375) cells, inducing early apoptosis at concentrations of 10, 15, and 20 μg/mL over 48 and 72 hours. Overall, the Fe3O4@β-CD nanosystem presents promising features as an adjunct in melanoma treatment, primarily due to its β-cyclodextrin coating that allows for potential drug loading, and its magnetic core that supports magnetically targeted therapy strategies.
Watz, C.G.; Mihali, C.-V.; Oprean, C.; Krauss Maldea, L.; Tatu, C.A.; Nicolov, M.; Sîrbu, I.-O.; Dehelean, C.A.; Socoliuc, V.; Moacă, E.-A. Fe3O4@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer Treatment. Nanomaterials 2025, 15, 1192. https://doi.org/10.3390/nano15151192