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Preparation of the multifunctional IBU/HP-β-CD hydrogel: impeding bacterial growth, controlled drug dispensation, and enhancing wound healing
A novel hydrogel system was developed by functionalizing oxidized regenerated cellulose (ORC) with l-lysine (L-Lys) through dynamic Schiff base linkages. This strategy endowed the hydrogel with natural antimicrobial activity due to the controlled release of L-Lys. Moreover, hydrophobic ibuprofen (IBU) was encapsulated using hydroxypropyl-β-cyclodextrin (HP-β-CD), effectively improving its solubility, dispersion, and delivery within the hydrophilic hydrogel matrix.
Antimicrobial assays revealed strong inhibition against E. coli and S. aureus, with inhibition zones of 25.3 ± 0.12 mm and 34.4 ± 0.11 mm, respectively. Degradation studies showed complete disintegration within 60 h, with easy removal using saline. In vivo wound healing experiments demonstrated 98.5 % wound closure within 13 days.
Jiayi Ni, Xielong Dong, Hao Wang, Yi Zhang, Juan Xu, Ting Wang (2025) Oxidized regenerated cellulose-based supermolecular hydrogel for controlled drug release: Integrating cyclodextrin-mediated hydrophobic drug distribution, wound-specific degradation, and multifunctional therapeutic effects.
International Journal of Biological Macromolecules 310 ( Part 3), 143445.
https://doi.org/10.1016/j.ijbiomac.2025.143445