Posted by In view of the overproduction of ROS and overexpression of cationic proteins in the inflammatory colon, the designed nanosystem was composed of oxidation-sensitive cyclodextrin (OX-CD), chitosan (CS) and pectin (AHP). OX-CD was utilized to load dexamethasone (DM) by the solvent evaporation method. CS and AHP with opposite charges were sequentially coated onto OX-CD to generate the nanosystems by the electrostatic self-assembly method.
The obtained AHP/CS/OX-CD-DM nanosystem (ACOC-DM) could maintain stability under the GI pH environments, and release drug in the inflammatory colon with pH/ROS sensitivity. Dual polysaccharide-coated ACOC-DM exhibited higher cellular uptake and anti-inflammatory efficacy in macrophages than single polysaccharide-coated CS/OX-CD-DM nanosystem (COC-DM). Orally administrated ACOC-DM could enhance inflammation targeting ability and therapeutic efficacy of DM in the ulcerative colitis mice.
Synthesis of oxidation-sensitive CD [2]
[1] Wang Y, Song X, Cui R, Luo X, Dong J, Wang H, Song C, Zhou Y, Cui S. Dual-Sensitive Carbohydrate-Based Nanosystem for Targeted Drug Delivery to Potentiate the Therapeutic Efficacy of Ulcerative Colitis. Int J Nanomedicine. 2024;19:8555-8572. https://www.dovepress.com/articles.php?article_id=95073
[2] Zhang D, Wei Y, Chen K, et al. Biocompatible reactive oxygen species (ROS)‐responsive nanoparticles as superior drug delivery vehicles. Adv Health Mater. 2015;4(1):69–76. https://doi.org/10.1002/adhm.201400299