Posted by An interesting patent application has been published disclosing CD-cellobiose or CD-lactose polymer for drug delivery targeted to the colon with the following abstract.
The invention provides a colonic microbiota responsive polymer characterized in that it is prepared by the polymerization of a response monomer and a linking monomer, wherein the response monomer is a cellobiose with a beta-(1,4)-glucoside bond or/and a lactose with a beta-galactoside bond; the linking monomer is a monomer that reacts with the hydroxyl group of the response monomer to form an ester or ether directly or by a crosslinking agent. The invention also provides a method for preparation of a colonic microbiota responsive polymer, a degradable film based on the polymer and a preparation method thereof. By means of the characteristics that beta-(1,4)-glucoside bond provided by cellobiose or/and beta-galactoside bond provided by lactose monomer unit in the polymer can specifically respond to the high abundance of microbiotas (beta-glucosidase or/and beta-galactosidase) in the colon to specifically degrade in the colon, a colon-targeted delivery system for diagnosis and treatment of colon diseases is constructed.
Zeyu Xiao, Gaoxian Chen, Kai Cui (2023) Colonic Microbiota Responsive Polymer And Its Preparation Method And Use. US Appl. 18474990. https://patentscope.wipo.int/search/en/detail.jsf?docId=US429380361