Posted by The auxiliary substancs used for improving the properties of cyclodextrin inclusion complexes via multicomponent complex formation are reviewed. Hydroxy acids (ascorbic acid, citric acid, tartaric acids, lactic acid, succinic acid), amino acids (arginine, L-threonine, glycine, glutamic acid, L-lysine, valine, isoleucine and aspartic acid), co-solvents (1-methyl-2-pyrrolidone, triethanolamine, monoethanolamine, diethanolamine), hydrophilic polymers (hydroxypropyl methylcellulose, polyvinyl pyrrolidone, sodium carboxymethyl cellulose, trimethyl chitosan), polyglycolized glycerides (gelucire), sugar alcohol (mannitol), surfactants (poloxamers), etc. form ternary complexes with the drug/CD system usually resulting in improved wettability, solubility, and bioavailability. The effect of sodium acetate, sodium salicylate, benzalkonium chloride, urea, nicotinamide. phospholipids, soybean lecithin, meglumine (N-acetyl glucamine), soluplus, and hyaluronic acid are also discussed.
This review helps through several examples for drug formulators to find the best auxiliary substance to his/her drug/CD complex.
Patil, P., Kumbhar, S., Ghorpade, V. (2024) Auxiliary Substances for Enhancement of Complexation Efficiency and Dissolution Rate of Drug-Cyclodextrin Complexes. International Journal of Drug Delivery Technology, 14(1), 598–608.