Posted by Bioactive glass has received considerable attention in both scientific and clinical settings due to its potential in tissue engineering and regenerative medicine. This material exhibits outstanding biocompatibility and beneficial biological activities, making it a versatile system for various applications, including implant coatings, drug delivery, tissue engineering, vascular regeneration,.[1] Depending on their glass network composition, bioactive glasses can be classified into silicate-derived, borosilicate/borate-derived, and phosphate-based variants. The unique structure of bioactive glass allows for the incorporation of various metallic ions like magnesium, zinc, strontium, and copper into the base composition. The in-situ release of these ions can produce specific therapeutic effects.[2] Additionally, mesoporous bioactive glass demonstrates excellent stability and high drug-loading capacity, making it an effective tool for targeted drug delivery. [3]
A recent study showed that the magnesium-doped mesoporous bioactive glass induced phenotypic transformation of macrophages, reducing the secretion of inflammatory factors, while promoting the proliferation of vascular endothelial cells and angiogenesis. Ultimately, these beneficial activities improved cardiac function. [4]
[1] Baino F, Hamzehlou S, Kargozar S. Bioactive glasses: where are we and where are we going. J Funct Biomater. 2018;9(1):25. https://doi.org/10.3390/jfb9010025
[2] Perić KŽ, Rider P, Alkildani S, et al. An introduction to bone tissue engineering. Int J Artif Organs. 2020;43(2):69–86. https://doi.org/10.1177/0391398819876286
[3] Kargozar S, Montazerian M, Hamzehlou S, et al. Mesoporous bioactive glasses: promising platforms for antibacterial strategies. Acta Biomater. 2018;81:1–19. https://doi.org/10.1016/j.actbio.2018.09.052
[4] Yu W, Ding J, Chen J, Jiang Y, Zhao J, Liu J, Zhou J, Liu J. Magnesium Ion-Doped Mesoporous Bioactive Glasses Loaded with Gallic Acid Against Myocardial Ischemia/Reperfusion Injury by Affecting the Biological Functions of Multiple Cells. Int J Nanomedicine. 2024;19:347-366
https://doi.org/10.2147/IJN.S444751