Cyclodextrin Host–Guest Recognition in Glucose-Monitoring Sensors

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A recent review has been published with the above title, exploring the role of cyclodextrins (CDs) in glucose monitoring (GM) sensors.

The development of non-invasive, rapid, accurate, sensitive, selective, and stable systems for continuous monitoring of blood glucose levels remains a challenge.

The introduction of CDs into GM systems not only impacts the sensitivity, selectivity, and detection limit of the monitoring process but also improves biocompatibility and stability.

In the sensors CDs are typically used as a part of the sensor’s recognition element, which is responsible for either specifically binding to glucose molecules or encapsulating the glucose sensing agent.

In the article the cyclodextrins are categorized into four groups:

  • CD-modified boronic acid derivatives
  • CD-modified mediators,
  • CD-modified nanoparticles,
  • CD-modified functionalized polymers.

The summarized results show that a cost-efficient, selective and highly sensitive CD-based glucose sensor is not so far away.

Want to know more details?

  2. Siamak Javanbakht, Sima Darvishi, Faeze Dorchei, Maryam Hosseini-Ghalehno, Marjan Dehghani, Malihe Pooresmaeil, Yota Suzuki, Qurat Ul Ain, Leire Ruiz Rubio, Ahmad Shaabani, Takashi Hayashita, Hassan Namazi, and Abolfazl Heydari (2023) Cyclodextrin Host–Guest Recognition in Glucose-Monitoring Sensors. ACS Omega 2023, 8, 37, 33202–33228.

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