This review considers the pros and cons of the various synthetic methods used for the preparation of various cyclodextrin derivatives. The environmental aspects are very important in developing new methods. Great efforts has been made to find green alternatives to classical synthetic methods.
The physicochemical and chemical behavior of cyclodextrins often differs from the typical properties of classic organic compounds and carbohydrates. The usually poor solubility and complexing properties of cyclodextrins can require special techniques. By eliminating or reducing the amount of solvent needed (ultrasound assisted reactions and grinding methods), green alternatives can reform classical synthetic methods, making them attractive for environmentally friendly production and the circular economy. The lack of energy-intensive synthetic and purification steps could transform currently inefficient processes into feasible methods. Mechanochemical reaction mechanisms are generally different from normal solution-chemistry mechanisms. The absence of a solvent and the presence of very high local temperatures for microseconds facilitate the synthesis of cyclodextrin derivatives that are impossible or difficult to produce under classical solution-chemistry conditions. Although mechanochemistry does not provide a general solution to all problems, several good examples show that this new technology can open up efficient synthetic pathways.
László Jicsinszky *ORCID,Federica Rossi,Roberto Solarino andGiancarlo Cravotto (2023) Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives. Molecules 28(2), 467; https://doi.org/10.3390/molecules28020467