CDs might be promising candidates for therapeutic and diagnostic purposes widely used in biomedicine. These structures can be chemically modified into branched star-copolymers forming various nanoparticles (NPs). It is now recognized that when NPs come into contact with blood, proteins adsorb to their surface, creating what is known as a protein corona. Protein coronas are very easy to form, altering the biological capabilities of nanosystems, particularly tissue accumulation, cellular uptake, antibody clearance, payload excretion profile, and toxicity. Therefore, these properties of protein corona could be harnessed to develop personalized remedies for every individual with high precision and speed. In this review, the ongoing research in biomedical fields using CD-based centered, pendant, and terminated polymers and their interactions with protein corona for theranostic applications is surveyed. Overall, a perusal of information concerning this novel approach in biomedicine will help to implement this methodology based on host-guest interaction to improve therapeutic and diagnostic strategies.
Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications
Donya Esmaeilpour, Jens Albert Broscheit, Sergey Shityakov: Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications. Int. J. Mol. Sci. 2022, 23(21), 13505; https://doi.org/10.3390/ijms232113505
Academic Editors: Francesco Trotta, Antonino Mazzaglia and Lajos Szente