Algae motors embedded in a degradable capsule for drug delivery

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An innovative way to prolong the retention time of drugs in the gastrointestinal tract was published in Science Robotics.

The use of micromotors for active drug delivery via oral administration has recently gained considerable interest. However, efficient motor-assisted delivery into the gastrointestinal (GI) tract remains challenging, owing to the short propulsion lifetime of currently used micromotor platforms. Here, an efficient algae-based motor platform was reported on, which takes advantage of the fast and long-lasting swimming behavior of natural microalgae in intestinal fluid to prolong local retention within the GI tract. Fluorescent dye or cell membrane–coated nanoparticle functionalized algae motors were further embedded inside a pH-sensitive capsule to enhance delivery to the small intestines. In vitro, the algae motors displayed a constant motion behavior in simulated intestinal fluid after 12 hours of continuous operation. When orally administered in vivo into mice, the algae motors substantially improved GI distribution of the dye payload compared with traditional magnesium-based micromotors, which are limited by short propulsion lifetimes, and they also enhanced retention of a model chemotherapeutic payload in the GI tract compared with a passive nanoparticle formulation.

The system does not contain cyclodextrin as yet but why not to utilize the advantages of CD-complexation and micromotors in drug delivery?

Gastrointestinal tract drug delivery using algae motors embedded in a degradable capsule
Fangyu Zhang, Zhengxing Li, Yaou Duan, Amal Abbas, Rodolfo Mundaca-Uribe, Lu Yin, Hao Luan, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang, Joseph Wang (2022) Gastrointestinal tract drug delivery using algae motors embedded in a degradable capsule. Science Robotics 7, DOI: 10.1126/scirobotics.abo4160

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