yellow green and red medication pill blister pack

Bacterioboat – a novel concurrent of CD-enabled drug delivery

Posted by

In a recent study published in Science Advances, Diptiman Choudhury, a biochemist at the Thapar Institute of Engineering and Technology, developed a new method for increasing a drug’s release time: transforming bacteria into a drug-transporting boat. The “bacterioboat” system encapsulates drug-loaded mesoporous nanoparticles in the biofilm coating of L. reuteri  bacteria. This biofilm contains sugars and mucus-binding proteins that enable the therapeutic bacteria to anchor within the intestinal lining for multiple days, promoting sustained release of the drug from the biofilm coating.  

Choudhury’s team tested the bacterioboat system’s drug-delivery capabilities in a tumor-bearing mouse model. Plasma concentrations of the orally delivered anticancer drug 5-fluorouracil (5-FU) peaked at three hours and were no longer detectable eight hours after administration. However, 5-FU delivered by bacterioboat persisted in circulation for up to 24 hours. 

Mice that received a standard orally-delivered drug and those that received a half-dose of the bacterioboat delivered drug showed equivalent reductions in their tumors, demonstrating that bacterioboat allows for smaller drug quantities to produce a clinically significant effect. In a measurement of side effects, the half-dose of bacterioboat caused no liver toxicity, while the full dose of the conventionally-delivered drug caused some liver capillary destruction. 

Fig. 1.. BB synthesis and morphology. (A) Schematic representation of the synthesis of BB with in situ and ex situ loading protocol for drugs of choice. (B) FE-SEM image of L. reuteri cells. (C) FE-SEM image of freshly prepared BB showing chitosan nanoparticles on the cell surface. (D) Enlarged view of black box area of (C) illustrating the sponge ball–shaped nanoparticles of 15 to 25 nm in size with a pore diameter of around 2 to 3 nm.

Kaur P, Ghosh S, Bhowmick A, Gadhave K, Datta S, Ghosh A, Garg N, Mahajan RL, Basu B, Choudhury D. Bacterioboat-A novel tool to increase the half-life period of the orally administered drug. Sci Adv. 2022 Mar 11;8(10):eabh1419. doi: 10.1126/sciadv.abh1419

https://www.drugdiscoverynews.com/bacterial-boats-deliver-drugs-15494

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.