Matthieu Sollogoub, professor of Biological and Supramolecular Glycochemistry at Sorbonne University gave a plenary lecture at the 20th International Cyclodextrin Symposium. He has devoted his research to carbohyrate chemistry since his PhD. (“My favorite molecule is glucose! he said.) Among his ~140 scientific papers he has published over 15 papers in Angewandte Chemie (impact factor >15).
The title of his presentation at ICS 20 was a question: ARE WE DOOMED TO SEE CYCLODEXTRINS AS ARTIFICIAL PROTEINS?
Since Breslow’s “artificial enzyme”, Cyclodextrins have been seen as potential protein mimics. However, a bottle-neck for their development was the lack of efficient regioselective functionalization. Over the years, we delineated several strategies to access poly-heterofunctionalized cyclodextrins. However, not to step on the toes of the giants who used them as enzyme mimics, we purposedly developed cyclodextrins as platforms for metal centers to operate catalysis. However, we serendipitously found a way to encapsulate metals inside the cavity and were drawn back to enzyme mimickry. The same story happened with a project on transfection, where cyclodextrins unexpectedly self-assembled in a capsid-protein way (Fig. 1). (Abstract book)
- Breslow, R.; Overman, L. E. J. Am. Chem. Soc., 1970, 92, 1075-1077.
- Sollogoub, M. et al. Nature Commun., 2014, 5, 5354; Angew. Chem. Int. Ed., 2021, 60, 12090.
- Sollogoub, M. et al. Angew. Chem. Int. Ed., 2010, 49, 2314.
- Sollogoub, M. et al. Chem, 2017, 3, 174.
- Sollogoub, M. et al. Angew. Chem. Int. Ed., 2018, 57, 7753.