Evading Thermodynamic Constraints of Cyclodextrin-Drug Formulations

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Drug Development and Delivery has published on excipients with the title: SPECIAL FEATURE – Excipients: Far From Inactive summarizing the properties of various excipients.

BENEO’s pharma team is investigating the use of galenIQ in some new and emerg­ing pharmaceutical technologies, in­cluding how it can be used to make 2mm orodispersible minitablets that disintegrate in the oral cavity within 30 seconds.

CycloLab’s two examples illustrate how to prepare such oversaturated solution in which the low rate of drug crystallization enables the administration of the composition within a reasonable time limit. First, hydroxypropyl betadex (HPBCD) is a peculiar CD soluble in ethanol. Ethanol-soluble guest drug molecules might be co-processed with HPBCD in their common ethanolic solution. A second example is betadex sulfobutyl ether sodium (SBECD), as an ionic CD derivative often shows great pH-dependent variation on its solubilizing performance which can be utilized in the complex formation. Another strategy applicable for native alfa-, beta-, and gamma-CDs to cope with low stability constant interactions is offered by the application of a third component like a polymer or hydroxy acid. 

Daicel’s orally disin­tegrating tablets (ODTs) disinte­grate in the oral cavity within 30 seconds are a preferred choice for children.

Gelucire® series by Gattefossé are multifunctional excipients for solid self-emulsifying drug delivery systems (SEDDS) and low-temperature melt extrusion.

Shin Etsu’s excipients: AQOAT (Hypromellose Acetate Succinate or Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS)) and L-HPC (Low substi­tuted hydroxypropyl cellulose) are also introduced.

Read more: https://drug-dev.com/special-feature-excipients-far-from-inactive/


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