Controlled release formulation of dimethyldisulfide antifungal agent

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DMDS is a natural biological pesticide formed by the decomposition of soil fungi and bacteria. It controls soil nematodes and insect pests by reducing neuronal activity through mitochondrial dysfunction and activation ofneuronal KATP-channels. It provides good control of soil-borne diseases and nematodes, such as Meloidogyne spp.,Fusarium spp., and Phytophthor aspp., and can increase crop yield.

Dimethyl disulfide (DMDS), a soil fumigant, is an effective, broad-spectrum compound that often replaces bromomethane (MB) in the prevention and treatment of soil-borne diseases. However, the disadvantages of DMDS include toxicity, volatility, pungent odor, risk of human exposure, and environmental pollution. 

In this study, a DMDS-controlled release formulation was developed by encapsulating DMDS in the cavity of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). This formulation reduced DMDS usage and production costs. The efficacy of DMDS@HP-β-CD was similar to unformulated DMDS. The efficacy duration of the formulation was about two times longer than DMDS, and it was safer to use. This study reveals a cyclodextrin-DMDS formulation with reduced toxicity, longer duration, environmental safety and sustainability.

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