CD-related papers in Scientific Reports

Scientific reports (Nature) has published 10 cyclodextrin-related papers in the last 3 months. Here is a selection:

Parvez, S., Yadagiri, G., Gedda, M.R. et al. Modified solid lipid nanoparticles encapsulated with Amphotericin B and Paromomycin: an effective oral combination against experimental murine visceral leishmaniasis. Sci Rep 10, 12243 (2020). https://doi.org/10.1038/s41598-020-69276-5

Visceral leishmaniasis (VL), also known as Kala-Azar is the most severe form of leishmaniasis, a neglected tropical disease caused by the protozoan parasite Leishmania donovani. Monotherapy with anti-leishmanials has led to the development of drug-resistant parasites. Therefore, multidrug combination strategies have emerged as a viable option in the treatment of infectious diseases like tuberculosis, leprosy, and malaria. In this current study, the preparation and characterization of HPBCD modified solid lipid nanoparticles (SLNs) based combinational cargo system of Amphotericin B and Paromomycin are described. Employing a combination of in vitro and in vivo experiments, it was shown that HPBCD modified SLNs can demonstrate the enhanced anti-leishmanial activity with reduced toxicity when administered orally.

Sheng, N., Ma, Z., Zhou, Y. et al. Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function. Sci Rep 10, 14246 (2020). https://doi.org/10.1038/s41598-020-71198-1

The findings reveal a protective role for 25-hydroxycholesterol (25-HC) in Dextran sulfate sodium-induced colitis. Supplementation with exogenous 25-HC solubilized with HPBCD ameliorates disease symptoms, which provides a new therapeutic strategy for ulcerative colitis.

Babazadeh, S., Moghaddam, P.A., Keshipour, S. et al. Colorimetric sensing of imidacloprid in cucumber fruits using a graphene quantum dot/Au (III) chemosensor. Sci Rep 10, 14327 (2020). https://doi.org/10.1038/s41598-020-71349-4

A very simple method for the colorimetric detection of imidacloprid using a graphene quantum dot/Au (III) chemosensor was developed and compared with β-cyclodextrin polymer functionalized reduced graphene oxide modified glassy carbon electrode

Wytinck, N., Sullivan, D.S., Biggar, K.T. et al. Clathrin mediated endocytosis is involved in the uptake of exogenous double-stranded RNA in the white mold phytopathogen Sclerotinia sclerotiorum. Sci Rep 10, 12773 (2020). https://doi.org/10.1038/s41598-020-69771-9

RNA interference (RNAi) technologies have recently been developed to control a growing number of agronomically significant fungal phytopathogens, including the white mold pathogen, Sclerotinia sclerotiorum. Exposure of this fungus to exogenous double-stranded RNA (dsRNA) results in potent RNAi-mediated knockdown of target genes’ transcripts, but it is unclear how the dsRNA can enter the fungal cells. In this study, using live cell imaging, transgenic fungal cultures and endocytic inhibitors, it was determined that the uptake mechanism in S. sclerotiorum occurs through clathrin-mediated endocytosis. Methyl-beta-cyclodextrin (MBCD), which inhibits clathrin-independent processes such as caveolae mediated endocytosis and lipid raft formation, was also tested.