Mycotoxins are toxic secondary metabolites of filamentous fungi. Zearalenone is a xenoestrogenic mycotoxin produced by Fusarium species. Plants commonly form less toxic hydrophilic conjugates from mycotoxins; these are called as “masked mycotoxins”, due to their challenging analytical determination. Zearalenone-14-glucoside (Z14G) is one of the most dominant masked mycotoxin produced from zearalenone. Z14G exerts lower toxicity than zearalenone; however, zearalenone is formed after its deglycosylation in the gastrointestinal tract. As a recent study highlighted, cyclodextrins (CDs) can entrap Z14G and insoluble beta-CD bead polymer successfully decrease the Z14G content of aqueous solutions . Previous studies reported the significant interactions of CDs with zearalenone and zearalenols [2-5]. The complex formation with CDs results in the strong increase in the fluorescence signal of these mycotoxins. Furthermore, it was also demonstrated that insoluble beta-CD bead polymer can effectively remove zearalenone from aqueous buffers and from spiked corn beer samples . Despite the previous observations regarding zearalenone and zearalenols, it was not obvious that CDs can accommodate Z14G because the masked mycotoxin possesses a large hydrophilic glucose part. In a recent study, the interaction of Z14G with beta- and gamma-CDs (native as well as methyl and hydroxypropyl derivatives) was tested . Z14G formed the most stable complexes with gamma-CDs under acidic and close to neutral conditions (K ≈ 10^3 L/mol), during which the fluorescence signal of Z14G considerably increased. In addition, insoluble beta-CD bead polymer strongly reduced the Z14G content of aqueous solutions . Based on these observations, CD technology may be a promising tool to develop mycotoxin binders which can remove both parent mycotoxins and some of their metabolites (e.g., masked mycotoxins) from aqueous solutions (including beverages).
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 Poór M, Faisal Z, Zand A, Bencsik T, Lemli B, Kunsági-Máté S, Szente L, Removal of zearalenone and zearalenols from aqueous solutions using insoluble beta-cyclodextrin bead polymer. Toxins 2018, 10, E216. (https://www.mdpi.com/2072-6651/10/6/216)