The revival of cyclodextrins as active pharmaceutical ingredients
Discovered in 1891, cyclodextrins, derived from starchy food, have found many applications in the cosmetic, agriculture, food and pharmaceutical industries
Tag: neuromuscular block
The Use of Sugammadex as Rescue Therapy Following Inadequate Reversal With Neostigmine – Clinical trial
Neuromuscular blocking agents (NMBAs) are commonly used in the practice of anesthesiology for skeletal muscle relaxation to facilitate tracheal intubation,
Serving patient’s safety and comfort: Effects of sugammadex vs. neostigmine on postoperative nausea, vomiting and pulmonary complications following general anesthesia.
A recent study published by Korean scientists compared the effect of sugammadex with that of neostigmine in terms of the
Neostigmine vs. sugammadex: on postoperative nausea and vomiting (PONV) after general anaesthesia
Sugammadex (SGM) is the first cyclodextrin derivative approved as an API, the result of a rational drug design, with a
Efficacy and safety of sugammadex for neuromuscular blockade reversal in pediatric patients: an updated meta-analysis of randomized controlled trials with trial sequential analysis
Background: A recent survey revealed that extensive off-label use of sugammadex in pediatric anesthesia deserved particular attention. The present study
Sugammadex in Colorectal and da Vinci Surgery
Traditionally, reversal of neuromuscular blocking agents following the completion of surgery was achieved with cholinesterase inhibitors. Recently, sugammadex has been
Comparison of Selective Relaxant Binding Agent Adamgammadex Sodium with Sugammadex for Reversing Rocuronium-Induced Deep Neuromuscular Block
Zhao et al. reported on a phase IIa, single-center, randomized, open-label, and dose-finding study that enrolled 35 patients under general
Sugammadex, the Guardian of Deep Muscle Relaxation During Conventional and Robot-Assisted Laparoscopic Surgery: A Narrative Review.
High intra-abdominal pressure induced by artificial pneumoperitoneum can obviously impair respiratory and circulatory functions and has a negative effect on
Carboxymethyl-γ-cyclodextrin, a novel selective relaxant binding agent for the reversal of neuromuscular block induced by aminosteroid neuromuscular blockers: an ex vivo laboratory study
Residual neuromuscular block at the end of surgery may compromise the patient’s safety. The risk of airway complications can be