Posted by A preprint of a manuscript dealing with lessons learnt from a space project involving the stability study of remdesivir/cyclodextrin complex is available. The full text authored by Hungarian scientists from Innostudio, Cyclolab as well as Research Centre for Natural Science and National Drug Research and Development Laboratory, Budapest is available on researchsquare [1].
Remdesivir / sulfobutylether beta-cyclodextrin complex was stored in two separate flight experiments on the International Space Station (ISS). While HPLC/MS studies revealed no degradation of the cyclodextrin excipient in any of the samples investigated in both missions, remdesivir purity analysis of the complex after the first mission revealed different stabilities and altered degradation in space and on Earth. This latter interesting finding was not supported by the second mission, where no differences in the drug stabilities were identified. This anomaly highlighted the importance of standardization together with increased control of the variable parameters during the entire space missions and the terrestrial control experiments.