This review on SBECD and its complexes summarizes the properties and applications with special emphasis on the effect of degree of substitution (DS). The main field is the use of SBECD as a solubilizer. Within the field of pharmaceutics, SBE-β-CD acts also as a “protective agent” and can be utilized for fine-tuning pKa values. Furthermore, it serves as an integral part of a matrix, resembling a “clamp,” effectively securing pharmaceuticals. In pharmaceutical analysis, SBE-β-CD is frequently employed for the separation of chiral substances.
The utilization of SBE-β-CD in formulations such as nanoparticles, hydrogels, and nanosponges have been thoroughly studied.
In the field of biomedical engineering, the combination of AIE dyes (dyes exhibiting the aggregation-induced emission ) with SBE-β-CD results in two mechanisms for fluorescence enhancement. The first mechanism involves the host impeding the non-radiative processes of the dye. The second mechanism arises from the aggregation caused by the binding of several guests with the host, hindering non-radiative processes of dyes.
SBE-β-CD is currently marketed under trade names like Captisol®, Dexolve® and others, with an average DS ranging from 6.2 to 6.9.
Jiaqi Huang, Xiaofeng Wang, Ting Huang, Yang Yang, Jiasheng Tu, Jian Zou, Huiying Yang, Rui Yang (2024) Application of sodium sulfobutylether-β-cyclodextrin based on encapsulation. Carbohydrate Polymers 333, 121985. https://doi.org/10.1016/j.carbpol.2024.121985