According to the Cyclodextrin News Library Database, the first description of the paracetamol (acetaminophen)–beta-cyclodextrin complex, published in 1980, is partly associated with a research group working in a laboratory that later became Cyclolab Ltd. [1].
Since the first public note on this complex, beta-cyclodextrin formulated paracetamol (alone or in combination with other APIs) has stood out for its versatility, being used in a wide range of pharmaceutical forms like no other. In the following tables and figures, this diversity is illustrated with a long list of approved dosage forms.
Table 1. Paracetamol (acetaminophen)–beta-cyclodextrin complex in marketed pharmaceuticals
| Actives | Trade name | Formulation | Manufacturer |
| Acetaminophen | 7T GummyES Acetaminophen Chewable Gels | tablet, chewable | 7T Pharma, USA |
| Aceclofenac + Thiocolchicoside + Paracetamol | Entaflam | tablet | Bionovics Pharm. (India) |
| Aceclofenac + Trypsin + Bromelain + Rutoside | Bextrin Total Capsule | capsule | Pharmanova India Drugs |
| Acetaminophen + Chlorpheniramine maleate + Dextromethorphan hydrobromide | Alka-Seltzer Plus Cold & Flu FizzyChews | tablet, chewable | Bayer Healthcare |
| Chlorpheniramine maleate + acetaminophen | Cold Remedy Soothing | tablet | Foshang Dezhong Pharm. (China) |
| Chlorpheniramine maleate + acetaminophen +Chinese herbs | “Wei C Yin Qiao Pian” for flu and colds | tablet | Guizhou Bailin Pharm. (China) |
Figure 1. Package of 7T GummyES Acetaminophen Chewable Gels (source: drugs.com)
Not only final dosage forms with native beta-cyclodextrin are marketed, but those formulated with hydroxypropyl betadex are also commercially available.
Table 2. Paracetamol (acetaminophen)–hydroxypropyl betadex complex in marketed pharmaceuticals
| Actives | Trade name | Formulation | Manufacturer |
| Acetaminophen | Paracetamol, Headache man, no more pills!, One shot, Calmour childrens acetaminophen strips chewable | infusion, chewable tablet, oral solution, dissolvable film | Uni-Pharma, 7T Pharma, Calmour |
Figure 2. Package of Headache man, no more pills!, One shot (source: https://dailymed.nlm.nih.gov/)
Figure 3. Package of Calmour childrens acetaminophen strips chewable (source: https://dailymed.nlm.nih.gov/)
References:
[1] Sztatisz, J.; Gal, S.; Komives, J.; Stadler-Szoke, A.; Szejtli, J.: Thermoanalytical investigations on cyclodextrin inclusion compounds. Therm. Anal., [Proc. Int. Conf. Therm. Anal.], 6th, Volume 2, 487- 93., 1980 Edited by: Hemminger, W. Birkhaeuser: Basel, Switzerland