The recently published patent application relates to ophthalmic compositions containing solid complexes of active pharmaceutical ingredient such as dexamethasone and cyclodextrin, such as gamma-cyclodextrin, to their method of preparation and their uses. The compositions can include an active agent drug/cyclodextrin complex substantially dissolved in an aqueous eye drop vehicle. The ophthalmic composition is generally in the form of a microsuspension including an active agent complex having a diameter of less than about 100 μm.
The novelty is based on the aggregation of the complex resulting in microparticles able to reach the intraocular tissues.
T. Loftsson, Z. Fülöp: Preparation of solid cyclodextrin complexes for ophthalmic active pharmaceutical ingredient delivery. US Patent App. 19/051,044, published: US20250177561A1 (2025-05-06)
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