Electrospun poly-ε-caprolactone (PCL) fibers (mats) loaded with inclusion complex of sulfobutyl ether β-cyclodextrin sodium salt (SB-β-CD) with dexamethasone (Dex) were developed, and their structural characteristics and desorption properties were studied. Initially, inclusion complex of SB-β-CD with Dex was prepared and complexation between these components was confirmed by FTIR-spectroscopy, differential scanning calorimetry (DSC), X-ray diffraction (XRD)and thermal mass spectrometry. Both neat PCL fibers (mats) and those filled with the inclusion complex were produced via electrospinning technique from chloroform-DMSO solutions. One part of the solution was used to obtain a film by casting on a teflon substrate. Features of the structural, morphological, thermophysical of the electrospun PCL mats were analyzed by XRD, scanning electron microscopy, DSC, and desorption behavior as well. More than 80% of the fibers obtained have diameters in the range of 180-400 nm and the average diameter of unloaded fibers is found to be 380.47 nm, which is almost 2.5 times smaller than in loaded fibers. The data of the drug release kinetics evidence that the desorption of dexamethasone from PCL matrix is significantly accelerated in saline compared to the release this drug in water. The elaborated nanofiber materials could be considered as potential objects for further investigations as drug release systems.
Larisa Kobrina, Anton Tymoshyk, Mykola Monastyretskyi, Valentyna Boiko, Sergiy Polishchuk, Sergii Sinelnikov, Dmytro Klymchuk, Sergii Riabov (2025) Electrospun poly-ε-caprolactone fibers loaded with inclusion complex of sulfobutyl ether β-cyclodextrin with dexamethasone as potential drug release systems. Carbohydrate Polymer Technologies and Applications 100726.
https://doi.org/10.1016/j.carpta.2025.100726