Psoriasis is an immune-mediated inflammatory skin disease where topical therapy is crucial. While various dosage forms have enhanced the efficacy of current treatments, their limited permeability and lack of targeted delivery to the dermis and epidermis remain challenges. Here the evolution of topical therapies for psoriasis was reviewes and a bibliometric analysis conducted from 1993 to 2023 using a predictive linear regression model [1]. This included a comprehensive statistical and visual evaluation of each model’s validity, literature profiles, citation patterns, and collaborations, assessing R variance and mean squared error (MSE). Furthermore, emerging drug delivery systems were shown for topical treatment, such as lipid-based, polymer-based, metallic nanocarriers, and nanocrystals, highlighting their advantages. This systematic overview indicates that future research should focus on developing novel drug delivery systems characterized by enhanced stability, biocompatibility, and drug-carrying capacity.
The following CD-related examples are mentioned:
- Quercetin-loaded liposomes were stabilized by hydroxypropyl-β-cyclodextrin (HPCD), which forms a stabilizing layer through hydrogen bonding with the liposome interface, enhancing stability [2]
- Cyclodextrin nanosponge-based hydrogel loaded with clobetasol propionate, which decreased oxidative stress markers and improved anti-psoriatic effects in a mouse tail model [3]
- Epichlorohydrin-β-Cyclodextrin/curcumin Binary System embedded in a Pluronic®/Hyaluronate Hydrogel, which increased curcumin solubility and permeation, showed anti-inflammatory solid effects in HaCaT cells, and notably decreased IL-6 expression [4]
[1] An P, Zhao Q, Hao S, Wang X, Tian J, Ma Z. Recent Advancements and Trends of Topical Drug Delivery Systems in Psoriasis: A Review and Bibliometric Analysis. Int J Nanomedicine. 2024;19:7631-7671
https://doi.org/10.2147/IJN.S461514
[2] Zhang Y, Gong S, Liu L, et al. Cyclodextrin-coordinated liposome-in-gel for transcutaneous quercetin delivery for psoriasis treatment. ACS Appl Mater Interfaces. 2023;15(34):40228–40240. https://doi.org/10.1021/acsami.3c07582
[3] Kumar S, Prasad M, Rao R. Topical delivery of clobetasol propionate loaded nanosponge hydrogel for effective treatment of psoriasis: formulation, physicochemical characterization, antipsoriatic potential and biochemical estimation. Mater Sci Eng C Mater Biol Appl. 2021;119:111605. https://doi.org/10.1016/j.msec.2020.111605
[4] Fernández-Romero AM, Maestrelli F, García-Gil S, et al. Preparation, characterization and evaluation of the anti-inflammatory activity of epichlorohydrin-β-cyclodextrin/curcumin binary systems embedded in a pluronic(®)/hyaluronate hydrogel. Int J Mol Sci. 2021;22(24). https://doi.org/10.3390/ijms222413566