Researchers from the United States 🇺🇸 developed fast-dissolving HPβCD nanofibers containing a three-drug combination of aspirin, paracetamol, and caffeine commonly used to treat headaches and migraines. The CD-based nanofibers incorporated all three drugs at ratios matching a commercial formulation and significantly improved dissolution, disintegration, and drug release compared to powder. The work highlights the potential of electrospun CD nanofibers as a fast-dissolving alternative to conventional tablets for acute pain treatment.
Asli Celebioglu, Mahmoud Aboelkheir, Tamer Uyar (2026) Fast-dissolving cyclodextrin nanofibers loaded with acetylsalicylic acid, paracetamol and caffeine combination for the pain treatment.
International Journal of Pharmaceutics 702, 127211. https://doi.org/10.1016/j.ijpharm.2026.127211.
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