A novel adsorbent β-cyclodextrin-modified pectin was synthesized for removing cholesterol and bile salts from the gastric-intestinal passage. Different amounts of β-cyclodextrin were cross-linked to pectin by aldol condensation reaction via glutaraldehyde. The prepared β-cyclodextrin-modified pectins were successfully confirmed by characterization, showing a higher specific surface area and improved thermal stability with satisfactory cellular compatibility. The introduction of β-cyclodextrins dramatically improved the cholesterol adsorption capacity of pectin due to their hydrophobic cavities. Meanwhile, the modified pectins exhibited superior adsorption for sodium cholate than β-cyclodextrin or pectin itself, which was attributed to hydrophobic interactions.
Luyao Chen, Xu He, Yijing Pu, Hongxuan Wang, Jiankang Cao, Weibo Jiang,
Adsorption removal properties of β-cyclodextrin-modified pectin on cholesterol and sodium cholate,
Food Chemistry Volume 430, 2024, 137059. https://doi.org/10.1016/j.foodchem.2023.137059.