Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment

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Parkinson-disease-patient-derived cells presented differences in their energetic profile, imbalanced proliferation, apoptosis, mitophagy, and a reduced differentiation efficiency to tyrosine hydroxylase positive (TH+) neurons compared to controls’ cells. Correction of a patient’s point mutation ameliorated the metabolic properties and neuronal firing rates as well as reversing the differentiation phenotype, and reducing the increased astrocytic levels. Treatment with 2-hydroxypropyl-β-cyclodextrin increased the autophagy and mitophagy capacity of neurons concomitant with an improved dopaminergic differentiation of patient-specific neurons in midbrain organoids and ameliorated neurotoxicity in a mouse model.


Javier Jarazo, Kyriaki Barmpa, Jennifer Modamio, Cláudia Saraiva, Sònia Sabaté-Soler, Isabel Rosety, Anne Griesbeck et al. (2022) Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment. Movement Disorders 37, 80-94.
First published: 12 October 2021 https://doi.org/10.1002/mds.28810

2 comments

  1. This was great, I have been researching for a while now, and I think this has helped. Have you ever come across Health Natural Centre Parkinson’s disease HERBAL FORMULA (just google it). It is a smashing one of a kind product for reversing Parkinson’s completely. Ive heard some decent things about it and my buddy got amazing success with it.

  2. My grandma has Parkinson’s disease, she is about 75 years old it was detected 7 years ago. Right now it’s getting more difficult to live for her, because of stiff muscles she can’t even move. L-dopa and carbidopa medicines are given, but won”t give much relief. She can”t eat food and the skin is damaging forming ganglia. I thought this might be the last stage and the medications she was given did not help at all, so I started to do alot of research on natural treatments, I was introduced to Health Natural Centre and their Parkinson’s Herbal Protocol. She started on the Parkinson’s Treatment last year, her symptoms gradually diminished including her Tremors, Body Weakness and Muscle Pains. Reach them at healthnaturalcentre.org , She is getting active again since starting this treatment, she is able to walk again ( down the street and back )she have also resumed exercising to strengthen muscles!! God Bless all PD Caregivers. Stay Strong, take small moments throughout the day to thank yourself, to love your self, and pray to whatever faith, star, spiritual force you believe in and ask for strength. I can personally vouch for these remedy but you would probably need to decide what works best for you.

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