Posted by D-maltose-clicked derivative of β-cyclodextrin (β-CD-M) was synthesized to compare and investigate its capability as an anticancer drug nanocarrier [1]. The success in the β-CD-M synthesis was validated via common characterization techniques: nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The SEM results indicate that the obtained β-CD-M molecule has a crystalline structure with a size of less than 100 nm. In the following, methotrexate (MTX) and doxorubicin (DOX) as the model of anticancer drugs were separately loaded in β-CD-M and their release profiles were obtained. The outcome of the cytotoxic assay against MCF 10A cells indicated that β-CD-M is biocompatible and could be used as a drug carrier. Overall, from the obtained results, the synthesized biocompatible β-CD-M with more drug loading capacity and a controlled release profile in comparison to unmodified β-CD could be proposed as a potential nanocarrier for anticancer drug delivery.
Otherwise, 6-O-α-Maltosyl-β-cyclodextrin hydrate can be purchased from Sigma Aldrich (https://www.sigmaaldrich.com/HU/en/product/sigma/m9672)
[1] Hediyeh Ebrahimpour, Yousef Toomari, Malihe Pooresmaeil &Hassan Namazi (2022) Cluster of D-maltose clicked to β-cyclodextrin: preparation and its application as a biocompatible drug delivery nanovehicle. Soft Materials Published online: 31 Dec 2021. https://doi.org/10.1080/1539445X.2021.2019056