Wan et al. (2021) published on the synthesis and potential utilization of β-CD modified with hyperbranced polyglycerol polymer and decorated with a number of hydrazide groups (named as β-CD-HPG-EBA-HH) in order to study the intracellular delivery of anticancer agent epirubicin (EPI). EPI was found to form dynamic bonds with β-CD-HPG-EBA-HH. These dynamic bonds showed pH responsiveness and therefore EPI could be released from carriers under environment with different pH. Dynamic light scattering measurements showed the self-assembly of the polymer loaded or unloaded with the drug (average diameter of the nanoparticles is 400 and 42 nm, respectively).
The biological assays demonstrated that EPI-loaded β-CD-HPG-EBA-HH complexes could still maintain its anticancer effects after internalization by HepG2 cells. Taken together, a novel method for construction of drug delivery systems with pH responsiveness have been developed in this work. This method is also useful for fabrication of many other drug delivery systems with great potential for biomedical applications.
Weimin Wan, Hui Ouyang, Zhihui Jiang, Yushun Cui, Junmao Lia, Mingzhen Hea, Shilin Yang, Xiaoyong Zhang, Yulin Fenga, Yen Wei (2021) Synthesis and intracellular drug delivery applications of hyperbranched polymers functionalized β-cyclodextrin. Colloid and Interface Science Communications 42, 100425 https://doi.org/10.1016/j.colcom.2021.100425