Inclusion complex of chrysin with sulfobutyl ether-β-cyclodextrin

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The work of Kulkarni and Belgamvar [1] demonstrates the impact of sulfobutyl ether-β-cyclodextrin (SBE-β-CD) complexation on the solubility, dissolution and pH stability of the poorly soluble polyphenol chrysin (CHR) by freeze-drying technique.
Chrisin is a type of flavonoid. a component of several medicinal plants, such as chamomile. It is also found in honey, various fruits and vegetables, sych as carrots. It has low solubility and bioavailability.

Phase solubility indicated the 1:1 stoichiometry. FTIR, DSC, PXRD, and SEM analysis confirmed the formation of inclusion complex. Moreover, 1H NMR studies illustrated that the possible inclusion mode was through A-ring of the CHR which was further confirmed by molecular modelling. In addition, CHR/SBE-β-CD complex exhibited ∼108 times higher solubility and faster dissolution compared to CHR. The pH stability profile exhibited the protective effect of SBE-β-CD on the CHR at simulated pH. Also, in vitro cytotoxicity assay revealed an appreciable improvement in the anticancer activity of complex compared to free CHR, on MCF-7 and HeLa cell lines validating its superiority as a carrier.  

[1] Abhijeet Kulkarni, Veena Belgamwar (2020) Inclusion complex of chrysin with sulfobutyl ether-β-cyclodextrin (Captisol®):Preparation, characterization, molecular modeling and in vitro  anticancer activity. Journal of Molecular Structure 1128. DOI: 10.1016/j.molstruc.2016.09.025

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