Development of chitosan films containing β-cyclodextrin inclusion complex for controlled release of bioactives

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2-Phenyl ethanol is a natural compound, which have many applications due to its nice fragrance, bacteriostatic and antifungal character. It is naturally present in more than one hundred food products (cranberries, grapes, chives, Scottish spearmint oil, cheeses, cognac, rum, white wine, cocoa, black tea, filbert, cloudberries, beans, mushrooms, and endives) and is used in the food industry to improve taste and odor. However, it is difficult to keep it stable and it is highly volatile.

In this work, chitosan films with 2-phenyl ethanol were developed and inclusion complexes with cyclodextrins (CDs) were prepared in order to have a controlled release of 2-phenyl ethanol. β-CD was selected to develop the inclusion complex since it showed higher retention yield (45%, molar basis) than α- or γ-CDs. Chitosan films incorporated with β-CD:2-phenyl ethanol were homogeneous, transparent and colorless, and showed high mechanical resistance. Furthermore, the release results of the films without the inclusion complex indicated that 2-phenyl ethanol was evaporated during the film preparation, and only an 8% of the total bioactive was retained in the film, while more than 90% of 2-phenyl ethanol was retained in the films with the inclusion complex.phenylethanol1


  1. Zarandona, C. Barba, P. Guerrero, la Caba, J.Maté (2020) Development of chitosan films containing β-cyclodextrin inclusion complex for controlled release of bioactives. Food Hydrocolloids 104, 105720


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  1. For more detail click here:
    Chitosan Market size surpassed USD 1.5 billion in 2017 and will witness a CAGR of more than 20% between 2018 and 2024. Rising water treatment activities mainly in Asia Pacific is anticipated to boost product demand, which will have subsequent impact on the overall chitosan market size in the coming years. Product is extensively preferred as a flocculant to treat wastewater. It is an effective coagulant for organic as well as inorganic compounds which are present in the water.

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