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CDs became popular chiral selectors in capillary electrophoresis due to the versatility of their derivatives. The number of papers in Scopus (2736 on 05.03.2019) is increasing although the rate is not as high as it was around 2000 (see the figure above).
It is interesting to study the statistics on the various CD derivatives reported in the literature. Table 1 lists the number of papers using the given derivatives in 2017–2019 (about 150 papers were reviewed). Only those applied at least in 2 papers in this period are shown.
Table 1: Number of papers using CD derivatives used in capillary electrophoresis in 2017–2019
| >20 | 15–19 | 10–14 | 5–9 | 2–5 |
| BCD | GCD-sulfate | CMBCD | ACD | ACD-sulfate |
| BCD-sulfate | GCD | TRIMEB | ||
| HPBCD | SBEBCD | DIMEB | ||
| Me-BCD | HPACD | |||
| HPGCD | ||||
| HEBCD* | ||||
| CEBCD** | ||||
| heptakis(6-O-sulfo)-β-CD | ||||
| heptakis(2,3‐di‐O‐acetyl‐6‐sulfo)‐β‐cyclodextrin |
*Hydroxyethyl BCD
**Carboxyethyl BCD
Although they seem to be very useful for several separations, each of the various single isomer CD derivatives were applied only in one study:
- heptakis(2,3‐di‐O‐methyl‐6‐sulfo)‐β‐cyclodextrin
- heptakis(2-O-methyl-3,6-di-O-sulfo)-β-CD
- heptakis-(6-O-sulfobutyl-ether)-β-cyclodextrin sodium salt
- heptakis‐(2,3‐di‐O‐methyl‐6‐O‐carboxymethyl)‐β‐CD
- mono-(6-ethylenediamine-6-deoxy)-β-cyclodextrin
The interesting ionic liquid-functionalized CD (mono-6-deoxy-6-(4-amino-1,2,4-triazolium)-β-cyclodextrin chloride) was used also in one paper.